Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924113 | 0.76 | GRIN2B (0.59) | ALDH1A1NPC1GRIN2BMMP1MMP9 | |
| SCHEMBL17117224 | 0.75 | CHRM4 (0.67) | ALDH1A1KMT2AEPHX2MEN1 | |
| SCHEMBL1575641 | 0.74 | CHRM4 (0.54) | ALDH1A1HRH3KMT2AEPHX2 | |
| SCHEMBL640772 | 0.74 | F2R (0.43) | ALDH1A1GAAF2RNAMPT | |
| SCHEMBL23390124 | 0.74 | RORC (0.49) | F2RKMT2AMEN1NAMPTTP53 | |
| SCHEMBL31435444 | 0.74 | RORC (0.49) | F2RKMT2AMEN1NAMPTTP53 | |
| SCHEMBL13873671 | 0.74 | CYP2C9 (0.57) | RAB9AALDH1A1NPC1HRH3EPHX2 | |
| SCHEMBL1576084 | 0.73 | GAA (0.55) | RAB9AALDH1A1NPC1CYP3A4CYP2D6 | |
| SCHEMBL1575199 | 0.73 | GAA (0.55) | RAB9AALDH1A1NPC1CYP3A4CYP2D6 | |
| SCHEMBL5210565 | 0.73 | GAA (0.69) | RAB9AALDH1A1NPC1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954693-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062007-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |