Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 0.39 |
| ▸ | THRA | P10827 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282089 | 0.90 | THRB (0.38) | THRBTHRAKDM4ERAB9A | |
| SCHEMBL283325 | 0.79 | THRB (0.35) | THRBTHRA | |
| SCHEMBL4962486 | 0.76 | TUBB1 (0.30) | — | |
| SCHEMBL282013 | 0.74 | THRB (0.39) | THRBTHRAKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL282646 | 0.74 | THRB (0.45) | THRBTHRA | |
| SCHEMBL282363 | 0.73 | THRB (0.44) | THRBTHRA | |
| SCHEMBL3162662 | 0.73 | TUBB1 (0.39) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL281882 | 0.72 | THRB (0.36) | THRBTHRA | |
| SCHEMBL282959 | 0.72 | THRB (0.37) | THRBTHRAOPRM1OPRD1OPRK1 | |
| SCHEMBL283149 | 0.72 | THRB (0.43) | THRBTHRAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |