Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.47 |
| ▸ | HRH1 | P35367 | 6/20 | 0.46 |
| ▸ | CCR3 | P51677 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193030 | 0.86 | HRH1 (0.55) | UTS2RHRH1CCR3KCNH2SCN1A | |
| Hydrochloric Acid SCHEMBL5192556 | 0.85 | HRH1 (0.54) | UTS2RHRH1CCR3KCNH2SCN1A | |
| SCHEMBL4967049 | 0.79 | HRH1 (0.59) | UTS2RHRH1CCR3KCNH2SIGMAR1 | |
| SCHEMBL4969078 | 0.79 | HRH1 (0.52) | HRH1CCR3KCNH2HRH3 | |
| SCHEMBL4237496 | 0.78 | HRH3 (0.56) | HRH1CCR3HRH3TRPC6 | |
| SCHEMBL180455 | 0.78 | HRH1 (0.59) | HRH1CCR3KCNH2 | |
| SCHEMBL4969060 | 0.77 | HRH1 (0.54) | HRH1CCR3KCNH2 | |
| SCHEMBL4155719 | 0.77 | HRH1 (0.71) | HRH1CCR3KCNH2 | |
| SCHEMBL14110602 | 0.77 | HRH1 (0.71) | HRH1CCR3KCNH2 | |
| SCHEMBL4969419 | 0.77 | CCR3 (0.55) | HRH1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620400-B1 | piperidinylmethylpiperidine derivatives and their use as chemokine modulators | ASTRAZENECA AB (SE) | 2012-12-05 | — | — | EP | disclosed |
| EP-1625114-B1 | Piperidine derivatives for the the treatment of chemokine or H1 mediated diseases | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |