Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | CCNC | P24863 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5649144 | 0.85 | SMN1; SMN2 (1.00) | SMN1; SMN2POLBMAPTKMT2AMEN1 | |
| SCHEMBL6496190 | 0.82 | CYP1A2 (0.60) | SMN1; SMN2POLBMAPTKMT2AMEN1 | |
| SCHEMBL6656407 | 0.80 | MAPT (0.69) | SMN1; SMN2POLBMAPTKMT2AMEN1 | |
| SCHEMBL30014816 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBMAPTKMT2AMEN1 | |
| SCHEMBL6162165 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBMAPTKMT2AMEN1 | |
| SCHEMBL5100760 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBMAPTKMT2AMEN1 | |
| SCHEMBL7363076 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBMAPTKMT2AMEN1 | |
| SCHEMBL1146057 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBMAPTKMT2AMEN1 | |
| SCHEMBL5650522 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBMAPTKMT2AMEN1 | |
| SCHEMBL4389868 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963313-A2 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE (DGAT) | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007060140-A2 | INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE (DGAT) | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | WO | disclosed |