Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 19/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170482 | 0.93 | LTA4H (0.59) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2169368 | 0.89 | LTA4H (0.58) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2168518 | 0.88 | LTA4H (0.57) | LTA4HKCNH2EPHX2 | |
| SCHEMBL2171303 | 0.88 | LTA4H (0.56) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL4693392 | 0.88 | LTA4H (0.53) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2168340 | 0.86 | LTA4H (0.54) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2171119 | 0.86 | LTA4H (0.55) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2168205 | 0.85 | LTA4H (0.58) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2167796 | 0.85 | LTA4H (0.51) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2169221 | 0.85 | LTA4H (0.56) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100564-A1 | LTA4H MODULATORS AND USES THEROF | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | claimed |