Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 16/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5123093 | 1.00 | FBP1 (0.57) | FBP1EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL5115813 | 1.00 | FBP1 (0.57) | FBP1EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL4968920 | 0.90 | FBP1 (0.72) | FBP1EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL4968868 | 0.90 | FBP1 (0.72) | FBP1EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL4967305 | 0.90 | FBP1 (0.72) | FBP1EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL4968744 | 0.88 | FBP1 (0.58) | FBP1EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL4968201 | 0.88 | FBP1 (0.58) | FBP1EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL4967436 | 0.88 | FBP1 (0.58) | FBP1EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL4968371 | 0.88 | FBP1 (0.58) | FBP1EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL4972747 | 0.88 | FBP1 (0.58) | FBP1EGFRERBB2ERBB4ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461166-B2 | Anilinoquinazolinyl amide derivatives; radiolabels as bioprobes for Positron Emission Tomography and Single Photon Emission Computed Tomography, and as radiopharmaceuticals for radiotherapy; improved solubility, bioavailability, biostability | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2013-06-11 | — | — | US | disclosed |
| EP-1957468-A2 | POLYALKYLENE GLYCOL DERIVATIVES OF 4 - (PHENYLAMINO)QUINAZOLINES USEFUL AS IRREVERSIBLE INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE | T.K. Signal Ltd. (IL) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007029251-A2 | POLYALKYLENE GLYCOL DERIVATIVES OF 4- (PHENYLAMINO)QUINAZOLINES USEFUL AS IRREVERSIBLE INHIBITORS OF EPIDERMAL GR0WTH FACT0R RECEPTOR TYROSINE KINASE | T.K. SIGNAL LTD. (IL) | 2007-03-15 | — | — | WO | disclosed |