8-Oh-Dpat

8-Oh-Dpat

SCHEMBL496783

CCCN(CCC)C1CCc2cccc(O)c2C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 6/20 1.00
DRD2 P14416 5/20 1.00
DRD3 P35462 5/20 1.00
HTR7 P34969 4/20 1.00
HTR1D P28221 2/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2D6 P10635 1/20 1.00
TSHR P16473 1/20 1.00
HTR1B P28222 1/20 1.00
HTR2A P28223 1/20 1.00
HTR2C P28335 1/20 1.00
ADRA1A P35348 1/20 1.00
ADRA1B P35368 1/20 1.00
HTR2B P41595 1/20 1.00
HTR5A P47898 1/20 1.00
BLM P54132 1/20 0.97
ALDH1A1 P00352 1/20 0.97
LMNA P02545 1/20 0.97
PMP22 Q01453 1/20 0.97
DRD4 P21917 3/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
8-Oh-Dpat SCHEMBL29565039 1.00 HTR1A (1.00) HTR1ADRD2DRD3HTR7HTR1D
8-Oh-Dpat SCHEMBL1682330 1.00 HTR1A (1.00) HTR1ADRD2DRD3HTR7HTR1D
8-Oh-Dpat SCHEMBL1682347 1.00 HTR1A (1.00) HTR1ADRD2DRD3HTR7HTR1D
8-Oh-Dpat SCHEMBL29389900 1.00 HTR1A (1.00) HTR1ADRD2DRD3HTR7HTR1D
8-Oh-Dpat SCHEMBL1682286 0.99 BLM (1.00) HTR1ADRD2DRD3HTR7HTR1D
8-Oh-Dpat SCHEMBL1682320 0.99 BLM (1.00) HTR1ADRD2DRD3HTR7HTR1D
8-Oh-Dpat SCHEMBL1682308 0.99 BLM (1.00) HTR1ADRD2DRD3HTR7HTR1D
SCHEMBL8892193 0.95 HTR1A (1.00) HTR1ADRD2DRD3HTR7HTR1D
SCHEMBL8891873 0.94 HTR1A (0.90) HTR1ADRD2DRD3HTR7HTR1D
8-Oh-Dpat SCHEMBL29420387 0.91 HTR1A (0.82) HTR1ADRD2DRD3HTR7HTR1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12434068-B2 Accessing spinal networks to address sexual dysfunction THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-10-07 US claimed
EP-4299106-B1 ACCESSING SPINAL NETWORK TO ENABLE RESPIRATORY FUNCTION UNIV CALIFORNIA (US) 2025-09-03 EP claimed
EP-4468884-A1 LYMPH-RELEASING COMPOSITIONS OF FATTY ACIDS AND USES THEREOF FOR LYMPHATIC INCORPORATION AND SYSTEMIC DISEASE TREATMENT Amarin Pharmaceuticals Ireland Limited (IE) 2024-12-04 EP claimed
US-20240374541-A1 ENGAGING THE CERVICAL SPINAL CORD CIRCUITRY TO RE-ENABLE VOLITIONAL CONTROL OF HAND FUNCTION IN TETRAPLEGIC SUBJECTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-11-14 US claimed
US-20240252535-A1 CELLULAR COMPOSITION FOR TREATMENT OF DISEASES, DISORDERS OR CONDITIONS AND METHOD OF USE YZTHERAPEUTIC PERFORMANCE LTD. (IL) 2024-08-01 US claimed
EP-4299106-A2 ACCESSING SPINAL NETWORK TO ENABLE RESPIRATORY FUNCTION The Regents of The University of California (US) 2024-01-03 EP claimed
WO-2023146984-A1 LYMPH-RELEASING COMPOSITIONS OF FATTY ACIDS AND USES THEREOF FOR LYMPHATIC INCORPORATION AND SYSTEMIC DISEASE TREATMENT AMARIN PHARMACEUTICALS IRELAND LIMITED (IE) 2023-08-03 WO claimed
EP-4208177-A1 CELLULAR COMPOSITION FOR TREATMENT OF DISEASES, DISORDERS OR CONDITIONS AND METHOD OF USE Yztherapeutic Performance Ltd. (IL) 2023-07-12 EP claimed
US-11298533-B2 Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-04-12 US claimed
US-11123312-B2 Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-09-21 US claimed
WO-1996001107-A1 USE OF PHARMACEUTICAL AGENTS FOR RESTORING, ALLEVIATION, OR TREATMENT OF IMMUNODEFICIENCY, INCLUDING THE ALLEVIATION OR TREATMENT OF THE IMMUNE DYSFUNCTION RELATED TO INFECTION WITH HUMAN IMMUNODEFICIENCY VIRUSES (HIV) OR RELATED VIRUSES HOFMANN BO ARNE (DK) 1996-01-18 WO claimed
WO-1996001106-A1 USE OF PHARMACEUTICAL AGENTS FOR ALLEVIATION OR TREATMENT OF THE IMMUNE DYSFUNCTION RELATED TO INFECTION WITH HUMAN IMMUNODEFICIENCY VIRUSES (HIV) OR RELATED VIRUSES HOFMANN BO ARNE (DK) 1996-01-18 WO claimed
EP-0565274-A1 5-Ht1A agonists for improving primary memory and/or learning ELI LILLY AND COMPANY (US) 1993-10-13 EP claimed
EP-0345948-B1 USE OF 5-HT1A AGONISTS FOR THE MANUFACTURE OF A MEDICAMENT PROTECTING AGAINST ISCHAEMIC DAMAGE SMITHKLINE BEECHAM PHARMA GmbH (DE) 1993-08-18 EP claimed
US-5189037-A Mixture of 8-hydroxy-2-(dipropylamino)-1,2,3,4-tetrahydro-naphthalene and 1-(2-pyrimidyl)pyrazine PFIZER INC (US) 1993-02-23 US claimed
EP-0510837-A2 Synergistic combinations in the treatment of anxiety PFIZER INC. (US) 1992-10-28 EP claimed
US-5124346-A 8-hydroxy-2-(dipropylamino)tetralin and idazoxan PFIZER INC. (US) 1992-06-23 US claimed
US-5049588-A 5-hydroxytryptamine antagonist BEECHAM GROUP P.L.C. (GB) 1991-09-17 US claimed
US-4943428-A 8-HYDROX-2-(DI-N-PROPYLAMINO)TETRALIN WRIGHT STATE UNIVERSITY (US) 1990-07-24 US claimed
EP-0345948-A2 Use of 5-HT1A agonists for the manufacture of a medicament protecting against ischaemic damage SMITHKLINE BEECHAM PHARMA GmbH (DE) 1989-12-13 EP claimed