SCHEMBL4968182

SCHEMBL4968182

Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1-c1nc[nH]n1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3998980 0.85 NPC1 (0.30)
SCHEMBL2530857 0.82 PDK2 (0.36)
SCHEMBL1468064 0.81 RECQL (0.37) PDE3BPDE3A
SCHEMBL3359275 0.81 PDE3B (0.40) PDE3BPDE3A
SCHEMBL536510 0.81 PDE3B (0.36) PDE3BPDE3A
SCHEMBL29530772 0.79 TDP1 (0.36) PDE3BPDE3A
SCHEMBL112187 0.79 CA1 (0.33) PDE3BPDE3A
SCHEMBL740175 0.79 TDP1 (0.36) PDE3BPDE3A
SCHEMBL1864604 0.78 RECQL (0.34) PDE3BPDE3A
SCHEMBL739909 0.78 KDM4E (0.37) PDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1966195-A2 5-ARYL ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-09-10 EP claimed
WO-2007075459-A2 5-ARYL ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-07-05 WO claimed