Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4968409 | 0.81 | MAPT (0.33) | KDM4EMAPT | |
| SCHEMBL4970795 | 0.81 | KMT2A (0.34) | RAB9AALDH1A1MAPT | |
| SCHEMBL20602128 | 0.77 | AHR (0.34) | AHRMAPT | |
| SCHEMBL3811214 | 0.76 | KDM4E (0.46) | NPC1RAB9AKDM4EALDH1A1AHR | |
| SCHEMBL4968672 | 0.74 | MAP4K4 (0.49) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL23580639 | 0.72 | MAOB (0.42) | ALDH1A1 | |
| SCHEMBL20602282 | 0.71 | AHR (0.40) | NPC1RAB9AKDM4EALDH1A1AHR | |
| SCHEMBL20602236 | 0.71 | AHR (0.37) | NPC1RAB9AAHR | |
| SCHEMBL4968697 | 0.69 | MAPT (0.33) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL15447506 | 0.68 | CA1 (0.36) | NPC1RAB9AAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778685-B1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SANOL ARZNEI SCHWARZ GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1778685-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015737-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2006-02-16 | — | — | WO | disclosed |