Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4968423 | 0.81 | NPC1 (0.33) | RAB9AMAPTALDH1A1 | |
| SCHEMBL4968409 | 0.81 | MAPT (0.33) | KMT2AMAPTLMNA | |
| SCHEMBL4968672 | 0.74 | MAP4K4 (0.49) | RAB9AMAPTALDH1A1HSD17B10 | |
| SCHEMBL4968697 | 0.69 | MAPT (0.33) | KMT2ARAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL4970217 | 0.69 | ATM (0.38) | KMT2ARAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL25372062 | 0.67 | CYP11B2 (0.33) | ALDH1A1 | |
| SCHEMBL4967566 | 0.67 | MAPT (0.37) | KMT2ARAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL4968698 | 0.64 | — | — | |
| SCHEMBL9827147 | 0.62 | ALOX15 (0.35) | KMT2ARAB9AMAPTLMNA | |
| SCHEMBL9959674 | 0.62 | TDP1 (0.38) | RAB9AMAPTLMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778685-B1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SANOL ARZNEI SCHWARZ GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1778685-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015737-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2006-02-16 | — | — | WO | disclosed |