Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 19/20 | 0.56 |
| ▸ | CCR3 | P51677 | 19/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970174 | 0.92 | HRH1 (0.60) | HRH1CCR3KCNH2 | |
| SCHEMBL4969159 | 0.91 | HRH1 (0.57) | HRH1CCR3KCNH2 | |
| SCHEMBL4968109 | 0.87 | HRH1 (0.67) | HRH1CCR3KCNH2 | |
| SCHEMBL4969444 | 0.85 | HRH1 (0.59) | HRH1CCR3KCNH2 | |
| SCHEMBL4966840 | 0.85 | HRH1 (0.59) | HRH1CCR3KCNH2 | |
| SCHEMBL4969071 | 0.85 | HRH1 (0.66) | HRH1CCR3KCNH2 | |
| SCHEMBL4969473 | 0.83 | HRH1 (0.57) | HRH1CCR3KCNH2 | |
| SCHEMBL4969201 | 0.81 | HRH1 (0.64) | HRH1CCR3KCNH2 | |
| SCHEMBL5191259 | 0.81 | HRH1 (0.65) | HRH1CCR3KCNH2 | |
| Methane SCHEMBL5192428 | 0.80 | HRH1 (0.64) | HRH1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625114-B1 | Piperidine derivatives for the the treatment of chemokine or H1 mediated diseases | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |