Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 19/20 | 0.57 |
| ▸ | CCR3 | P51677 | 19/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4968656 | 0.91 | HRH1 (0.56) | HRH1CCR3KCNH2 | |
| SCHEMBL4970174 | 0.90 | HRH1 (0.60) | HRH1CCR3KCNH2 | |
| SCHEMBL4968109 | 0.86 | HRH1 (0.67) | HRH1CCR3KCNH2 | |
| SCHEMBL4968718 | 0.85 | HRH1 (0.62) | HRH1CCR3KCNH2 | |
| SCHEMBL4966840 | 0.84 | HRH1 (0.59) | HRH1CCR3KCNH2 | |
| SCHEMBL4969444 | 0.84 | HRH1 (0.59) | HRH1CCR3KCNH2 | |
| SCHEMBL4969428 | 0.82 | SIGMAR1 (0.50) | HRH1CCR3KCNH2 | |
| SCHEMBL4969201 | 0.82 | HRH1 (0.64) | HRH1CCR3KCNH2 | |
| SCHEMBL4969473 | 0.81 | HRH1 (0.57) | HRH1CCR3KCNH2 | |
| SCHEMBL4968548 | 0.79 | HRH1 (0.58) | HRH1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625114-B1 | Piperidine derivatives for the the treatment of chemokine or H1 mediated diseases | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |