Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.58 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.58 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | CDC25B | P30305 | 2/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10093416 | 1.00 | MEN1 (0.64) | MEN1KMT2AHPGDCSNK2A2CSNK2B | |
| SCHEMBL496852 | 0.88 | DYRK1A (0.71) | MEN1KMT2AHPGDCSNK2A2CSNK2B | |
| SCHEMBL497128 | 0.88 | DYRK1A (0.71) | MEN1KMT2AHPGDCSNK2A2CSNK2B | |
| SCHEMBL10093413 | 0.84 | DYRK1A (0.55) | MEN1KMT2AHPGDCSNK2A2CSNK2B | |
| SCHEMBL496866 | 0.84 | DYRK1A (0.55) | MEN1KMT2AHPGDCSNK2A2CSNK2B | |
| SCHEMBL497062 | 0.83 | CSNK2A2 (0.59) | MEN1KMT2AHPGDCSNK2A2CSNK2B | |
| SCHEMBL497063 | 0.83 | CSNK2A2 (0.59) | MEN1KMT2AHPGDCSNK2A2CSNK2B | |
| SCHEMBL497260 | 0.82 | KMT2A (0.66) | MEN1KMT2AHPGDCSNK2A2CSNK2B | |
| SCHEMBL497258 | 0.82 | KMT2A (0.66) | MEN1KMT2AHPGDCSNK2A2CSNK2B | |
| SCHEMBL5477062 | 0.81 | DYRK1A (0.59) | MEN1KMT2AHPGDCSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106214-B2 | 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as PI3 kinase inhibitors | MERCK SERONO SA (CH) | 2012-01-31 | — | — | US | claimed |
| EP-1648452-B1 | 2-IMINO-4-(THIO)OXO-5-POLYCYCLOVINYLAZOLINES FOR USE AS PI3 KINASE INHIBITORS | MERCK SERONO SA (CH) | 2009-07-22 | — | — | EP | claimed |
| US-8106214-B2 | 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as PI3 kinase inhibitors | MERCK SERONO SA (CH) | 2012-01-31 | — | — | US | disclosed |
| US-20070021447-A1 | 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021447-A1 | 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors | PI4K2B, PI4KA, PTK2B | MEN1 3203/4885KMT2A 3092/4885HPGD 1525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.