Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL11656570 | 0.79 | DAO (0.59) | ALDH1A1NPSR1MAPTKDM4EPKM | |
| SCHEMBL3093344 | 0.77 | DAO (0.65) | HPGDALDH1A1NPSR1MAPTKDM4E | |
| SCHEMBL12195803 | 0.73 | HPGD (0.53) | HPGDALDH1A1POLBNPSR1LMNA | |
| SCHEMBL16334956 | 0.73 | DAO (0.50) | ALDH1A1NPSR1MAPTKDM4EPKM | |
| SCHEMBL2637597 | 0.70 | HPGD (0.66) | HPGDALDH1A1YEATS4POLBMAPT | |
| SCHEMBL4157157 | 0.69 | HPGD (0.66) | HPGDALDH1A1YEATS4POLBLMNA | |
| SCHEMBL19396259 | 0.68 | NPC1 (0.44) | HPGDALDH1A1YEATS4POLBNPSR1 | |
| SCHEMBL22859910 | 0.68 | ALDH1A1 (0.40) | HPGDALDH1A1YEATS4POLBNPSR1 | |
| SCHEMBL10272950 | 0.67 | HCAR2 (0.55) | HPGDALDH1A1YEATS4POLBNPSR1 | |
| SCHEMBL27882567 | 0.67 | DAO (0.43) | ALDH1A1NPSR1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904472-A1 | THIOPHENE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | Nissan Chemical Industries, Ltd. (JP) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007010954-A1 | THIOPHENE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2007-01-25 | — | — | WO | disclosed |