Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496673 | 0.85 | MAPT (0.61) | MAPTTP53NPC1LMNARAB9A | |
| SCHEMBL496847 | 0.77 | MAPT (0.53) | MAPTTP53NPC1LMNARAB9A | |
| SCHEMBL496884 | 0.76 | MAPT (0.56) | MAPTTP53NPC1LMNARAB9A | |
| SCHEMBL2886423 | 0.75 | MAPT (1.00) | MAPTTP53NPC1LMNARAB9A | |
| SCHEMBL496780 | 0.72 | MAPT (0.60) | MAPTTP53NPC1LMNARAB9A | |
| SCHEMBL10664153 | 0.69 | MAPT (0.76) | MAPTTP53NPC1LMNARAB9A | |
| SCHEMBL496814 | 0.69 | MAPT (0.76) | MAPTTP53NPC1LMNARAB9A | |
| SCHEMBL5192240 | 0.68 | LTA4H (0.64) | MAPTTP53NPC1LMNARAB9A | |
| SCHEMBL10685990 | 0.68 | MAPT (0.72) | MAPTTP53NPC1LMNARAB9A | |
| SCHEMBL496638 | 0.67 | MAPT (0.63) | MAPTTP53NPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106047-B2 | (4-Methoxyphenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine; phosphodiesterase inhibitors; septic shock or vascular edema; neoangiogenesis or inflammatory disease | NYCOMED GMBH (DE) | 2012-01-31 | — | — | US | claimed |