Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | HPGD | P15428 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.68 |
| ▸ | TSHR | P16473 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 6/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10993573 | 0.89 | KDM4E (0.57) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL7057692 | 0.84 | KDM4E (0.70) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL3979676 | 0.84 | KDM4E (0.70) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL3810029 | 0.84 | LMNA (0.74) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL11948562 | 0.83 | KDM4E (0.68) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL17189835 | 0.83 | KDM4E (0.68) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL3006540 | 0.83 | KDM4E (0.68) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL9027382 | 0.83 | KDM4E (0.68) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL30390219 | 0.83 | KDM4E (0.68) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL27693950 | 0.83 | LMNA (0.73) | KDM4EHPGDALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879903-A1 | ETHER LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006120541-A1 | ETHER LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (US) | 2006-11-16 | — | — | WO | disclosed |