Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459050 | 0.66 | PTGS1 (0.41) | BRAFPTGS1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13784459 | 0.64 | BRAF (0.52) | BRAFPTGS1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL885559 | 0.64 | PTGS1 (0.40) | BRAFPTGS1SMN1; SMN2MAPTPOLB | |
| SCHEMBL4978131 | 0.63 | PTGS1 (0.63) | PTGS1KDM4ENPSR1ALDH1A1PTGS2 | |
| SCHEMBL12859488 | 0.62 | BRAF (0.47) | BRAFPTGS1SMN1; SMN2ALDH1A1 | |
| SCHEMBL18813591 | 0.62 | — | — | |
| SCHEMBL12871680 | 0.61 | PTGS1 (0.46) | BRAFPTGS1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3381554 | 0.61 | SMN1; SMN2 (0.43) | BRAFPTGS1SMN1; SMN2MAPTLMNA | |
| SCHEMBL3381488 | 0.61 | BRAF (0.43) | BRAFPTGS1SMN1; SMN2NPSR1PTGS2 | |
| SCHEMBL8952086 | 0.61 | NR3C1 (0.43) | BRAFPTGS1SMN1; SMN2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904454-A2 | PROCESS FOR THE PRODUCTION OF INTERMADIATES FOR THE PREPARATION OF TRICYCLIC BENZIMIDAZOLES | Nycomed GmbH (DE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006136552-A2 | PROCESS FOR THE PRODUCTION OF INTERMADIATES FOR THE PREPARATION OF TRICYCLIC BENZIMIDAZOLES | NYCOMED GMBH (DE) | 2006-12-28 | — | — | WO | disclosed |