Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.49 |
| ▸ | FLT1 | P17948 | 5/20 | 0.49 |
| ▸ | FLT4 | P35916 | 5/20 | 0.49 |
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4969262 | 0.83 | IRAK4 (0.53) | EGFRFGFR1FLT1FLT4KDR | |
| Trifluoroacetic Acid SCHEMBL4965758 | 0.81 | IRAK4 (0.57) | EGFRFGFR1FLT1FLT4KDR | |
| Trifluoroacetic Acid SCHEMBL4969504 | 0.74 | PDE10A (0.39) | EGFRFGFR1FLT1FLT4KDR | |
| Trifluoroacetic Acid SCHEMBL30264700 | 0.73 | KIT (0.46) | EGFRFGFR1FLT1FLT4KDR | |
| Trifluoroacetic Acid SCHEMBL22590116 | 0.71 | EGFR (0.67) | EGFRFGFR1FLT1FLT4KDR | |
| Trifluoroacetic Acid SCHEMBL29444171 | 0.71 | EGFR (0.67) | EGFRFGFR1FLT1FLT4KDR | |
| SCHEMBL22745192 | 0.70 | RPS6KB1 (0.43) | EGFRFGFR1FLT1FLT4KDR | |
| SCHEMBL29481245 | 0.70 | RPS6KB1 (0.43) | EGFRFGFR1FLT1FLT4KDR | |
| Trifluoroacetic Acid SCHEMBL1482241 | 0.70 | EGFR (0.69) | EGFRFLT4KDRERBB2ERBB4 | |
| SCHEMBL22164644 | 0.70 | ENPP1 (0.58) | EGFRKDRKDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899319-A2 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1893206-A2 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135649-A2 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |
| WO-2006135636-A2 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |