Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 19/20 | 0.70 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.70 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.70 |
| ▸ | HTR2C | P28335 | 1/20 | 0.70 |
| ▸ | PPARG | P37231 | 1/20 | 0.70 |
| ▸ | HTR2B | P41595 | 1/20 | 0.70 |
| ▸ | PPARD | Q03181 | 1/20 | 0.70 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL453046 | 1.00 | ADORA3 (0.70) | ADORA3ADORA1ADORA2AADORA2BHTR2C | |
| SCHEMBL8983111 | 0.90 | ADORA3 (0.75) | ADORA3ADORA1ADORA2AADORA2BHTR2C | |
| SCHEMBL449676 | 0.90 | ADORA3 (0.63) | ADORA3ADORA1ADORA2AADORA2BHTR2C | |
| SCHEMBL4971922 | 0.90 | ADORA3 (0.63) | ADORA3ADORA1ADORA2AADORA2BHTR2C | |
| SCHEMBL2445029 | 0.90 | ADORA3 (0.63) | ADORA3ADORA1ADORA2AADORA2BHTR2C | |
| SCHEMBL4969425 | 0.89 | ADORA3 (0.57) | ADORA3ADORA1ADORA2AADORA2BHTR2C | |
| SCHEMBL447583 | 0.89 | ADORA3 (0.57) | ADORA3ADORA1ADORA2AADORA2BHTR2C | |
| SCHEMBL25396739 | 0.89 | ADORA3 (0.73) | ADORA3ADORA1ADORA2AADORA2BHTR2C | |
| SCHEMBL7287853 | 0.89 | ADORA3 (0.73) | ADORA3ADORA1ADORA2AADORA2BHTR2C | |
| SCHEMBL1953889 | 0.87 | ADORA3 (0.70) | ADORA3ADORA1ADORA2AADORA2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976494-A1 | ADENOSINE A3 RECEPTOR AGONISTS FOR THE TREATMENT OF DRY EYE DISORDERS | Can-Fite Biopharma Ltd. (IL) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007086044-A1 | ADENOSINE A3 RECEPTOR AGONISTS FOR THE TREATMENT OF DRY EYE DISORDERS | CAN-FITE BIOPHARMA LTD. (IL) | 2007-08-02 | — | — | WO | disclosed |
| EP-1778239-A1 | ADENOSINE A3 RECEPTOR AGONISTS FOR THE TREATMENT OF DRY EYE DISORDERS INCLUDING SJOGREN'S SYNDROME | Can-Fite Biopharma Ltd. (IL) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006011130-A1 | ADENOSINE A3 RECEPTOR AGONISTS FOR THE TREATMENT OF DRY EYE DISORDERS INCLUDING SJOGREN’S SYNDROME | CAN-FITE BIOPHARMA LTD. (IL) | 2006-02-02 | — | — | WO | disclosed |