Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 11/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674674 | 0.81 | HSP90AA1 (0.51) | CRHR1HSP90AA1HSP90AB1HSD11B1MAPT | |
| SCHEMBL4975912 | 0.81 | HSP90AA1 (0.36) | CRHR1HSP90AA1HSP90AB1HSD11B1 | |
| SCHEMBL27610644 | 0.78 | MAP3K14 (0.48) | HSP90AA1HSP90AB1ROS1DPP4MAPT | |
| SCHEMBL4973922 | 0.78 | CRHR1 (0.37) | CRHR1HSP90AA1HSP90AB1HSD11B1DPP4 | |
| SCHEMBL4971002 | 0.76 | MAPT (0.36) | CRHR1HSP90AA1HSP90AB1DPP4MAPT | |
| SCHEMBL18952795 | 0.74 | CNR1 (0.41) | HSD11B1DPP4 | |
| SCHEMBL4972450 | 0.74 | GSK3B (0.44) | CRHR1HSP90AB1HSD11B1DPP4MAPT | |
| SCHEMBL4972454 | 0.73 | IDO1 (0.50) | MAPTHPGD | |
| SCHEMBL3327264 | 0.72 | IDO1 (0.47) | HSP90AA1HSP90AB1HSD11B1 | |
| SCHEMBL4971006 | 0.71 | PIM1 (0.48) | CRHR1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653970-A4 | GSK-3 INHIBITORS AND USES THEREOF | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2008-10-15 | — | — | EP | disclosed |
| EP-1653970-A2 | GSK-3 INHIBITORS AND USES THEREOF | CHIRON CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005039485-A2 | GSK-3 INHIBITORS AND USES THEREOF | CHIRON CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |