Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 6/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2023281 | 0.85 | ALDH1A1 (0.46) | EPHB3RIPK2LCKALDH1A1KDM4E | |
| SCHEMBL24566266 | 0.75 | EPHB3 (0.38) | EPHB3RIPK2LCKALDH1A1KDM4E | |
| SCHEMBL416200 | 0.74 | EPHB3 (0.56) | EPHB3RIPK2LCKALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL19119427 | 0.72 | EPHB3 (0.55) | EPHB3RIPK2LCKALDH1A1KDM4E | |
| SCHEMBL22050800 | 0.72 | EPHB3 (0.40) | EPHB3RIPK2LCKALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL30152645 | 0.72 | EPHB3 (0.55) | EPHB3RIPK2LCKALDH1A1KDM4E | |
| SCHEMBL4970380 | 0.70 | KDM4E (0.36) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL6450616 | 0.70 | NPC1 (0.54) | EPHB3RIPK2LCKALDH1A1KDM4E | |
| SCHEMBL21436533 | 0.70 | EPHB3 (0.63) | EPHB3RIPK2LCKALDH1A1KDM4E | |
| SCHEMBL1290470 | 0.70 | DRD3 (0.50) | EPHB3RIPK2LCKALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778685-B1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SANOL ARZNEI SCHWARZ GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1778685-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015737-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2006-02-16 | — | — | WO | disclosed |