SCHEMBL4970488

SCHEMBL4970488

Cc1cc(C)c2c(c1)NC(=O)[C@@H](CC(C)C)O2

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 2/20 0.45
CREBBP Q92793 1/20 0.45
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
USP2 O75604 1/20 0.37
GAA P10253 1/20 0.37
TSHR P16473 1/20 0.35
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
HSD17B10 Q99714 2/20 0.33
TP53 P04637 1/20 0.33
ALOX15 P16050 1/20 0.32
CRBN Q96SW2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4969998 1.00 BRD4 (0.45) BRD4CREBBPMEN1KMT2AUSP2
SCHEMBL4968992 0.84 MEN1 (0.41) BRD4MEN1KMT2AUSP2GAA
SCHEMBL4969941 0.81 BRD4 (0.44) BRD4MEN1KMT2AUSP2GAA
SCHEMBL4969561 0.79 BRD4 (0.46) BRD4MEN1KMT2AUSP2GAA
SCHEMBL4967583 0.78 BRD4 (0.44) BRD4MEN1KMT2AUSP2GAA
SCHEMBL4967580 0.78 BRD4 (0.44) BRD4MEN1KMT2AUSP2GAA
SCHEMBL4968331 0.78 BRD4 (0.44) BRD4MEN1KMT2AUSP2GAA
SCHEMBL4970043 0.77 BRD4 (0.48) BRD4MEN1KMT2AUSP2GAA
SCHEMBL4969003 0.76 BRD4 (0.34) BRD4MEN1KMT2AUSP2GAA
SCHEMBL4969007 0.76 BRD4 (0.34) BRD4MEN1KMT2AUSP2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1985297-A1 CARBOXYLIC ACID COMPOUND AND USE THEREOF Japan Tobacco, Inc. (JP) 2008-10-29 EP disclosed
US-20070197512-A1 Carboxylic Acid Compounds and Use Thereof JAPAN TOBACCO INC. (JP) 2007-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070197512-A1 Carboxylic Acid Compounds and Use Thereof GLS, SLC10A1, SOAT1 BRD4 3303/4885CREBBP 2067/4885MEN1 4288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.