Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 11/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4971397 | 0.98 | GABRA5 (0.51) | GABRA5HDAC4HDAC6HPGDSUSP30 | |
| SCHEMBL4971020 | 0.97 | GABRA5 (0.55) | GABRA5HDAC4HPGDSUSP30SMYD3 | |
| SCHEMBL4972209 | 0.94 | GABRA5 (0.50) | GABRA5HPGDSGRM5 | |
| SCHEMBL4973770 | 0.92 | GABRA5 (0.50) | GABRA5HPGDSGRM5 | |
| SCHEMBL4971806 | 0.91 | GABRA5 (0.53) | GABRA5HPGDSGRM5 | |
| SCHEMBL4971009 | 0.91 | GABRA5 (0.51) | GABRA5HDAC4HDAC6SMYD3 | |
| SCHEMBL4971725 | 0.90 | GABRA5 (0.49) | GABRA5HDAC4HDAC6SMYD3 | |
| SCHEMBL4971711 | 0.89 | GABRA5 (0.51) | GABRA5HDAC4SMYD3 | |
| SCHEMBL4970995 | 0.88 | GABRA5 (0.56) | GABRA5 | |
| SCHEMBL4973220 | 0.87 | MAPK14 (0.52) | GABRA5SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968973-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | claimed |
| WO-2007074078-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-05 | — | — | WO | claimed |
| EP-1968973-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007074078-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-05 | — | — | WO | disclosed |