Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022502 | 0.90 | MEN1 (0.43) | GSK3BMEN1KMT2ALMNAMAPT | |
| SCHEMBL7850973 | 0.86 | GSK3B (0.40) | GSK3BMEN1KMT2ALMNAHTT | |
| SCHEMBL7022779 | 0.86 | GSK3B (0.73) | GSK3BMEN1KMT2ALMNAKDM4E | |
| SCHEMBL7852739 | 0.85 | GSK3B (0.38) | GSK3BMEN1KMT2ALMNAMAPT | |
| SCHEMBL7022814 | 0.85 | MAPT (0.39) | GSK3BMEN1KMT2ALMNAHTT | |
| SCHEMBL4393725 | 0.85 | GSK3B (0.75) | GSK3BMEN1KMT2ALMNAKDM4E | |
| SCHEMBL4972797 | 0.84 | GSK3B (0.47) | GSK3BMEN1KMT2ALMNAKDM4E | |
| SCHEMBL4970968 | 0.84 | GSK3B (0.57) | GSK3BMEN1KMT2ALMNAKDM4E | |
| SCHEMBL7852234 | 0.84 | GSK3B (0.51) | GSK3BMEN1KMT2ALMNAKDM4E | |
| SCHEMBL7854664 | 0.83 | GSK3B (0.51) | GSK3BMEN1KMT2ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653970-A4 | GSK-3 INHIBITORS AND USES THEREOF | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2008-10-15 | — | — | EP | disclosed |
| EP-1653970-A2 | GSK-3 INHIBITORS AND USES THEREOF | CHIRON CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005039485-A2 | GSK-3 INHIBITORS AND USES THEREOF | CHIRON CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |