Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970607 | 0.90 | GSK3B (0.55) | MEN1KMT2AGSK3BSMN1; SMN2POLB | |
| SCHEMBL7850973 | 0.86 | GSK3B (0.40) | MEN1KMT2AGSK3BSMN1; SMN2POLB | |
| SCHEMBL7852170 | 0.85 | GSK3B (0.60) | MEN1KMT2AGSK3BSMN1; SMN2POLB | |
| SCHEMBL7250090 | 0.84 | GSK3B (0.60) | MEN1KMT2AGSK3BSMN1; SMN2POLB | |
| SCHEMBL7853884 | 0.84 | SMN1; SMN2 (0.35) | MEN1KMT2AGSK3BSMN1; SMN2POLB | |
| SCHEMBL7022685 | 0.84 | HTR7 (0.42) | GSK3BSMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL7855802 | 0.84 | MAPT (0.41) | MEN1KMT2AGSK3BSMN1; SMN2POLB | |
| SCHEMBL7852739 | 0.83 | GSK3B (0.38) | MEN1KMT2AGSK3BSMN1; SMN2POLB | |
| SCHEMBL7022814 | 0.83 | MAPT (0.39) | MEN1KMT2AGSK3BSMN1; SMN2POLB | |
| SCHEMBL5559057 | 0.76 | GSK3B (0.62) | MEN1KMT2AGSK3BSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |