SCHEMBL4970664

SCHEMBL4970664

O=C(O)Cc1ccc(CCCCc2ccccc2)cc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.74
ALDH1A1 P00352 2/20 0.71
HPGD P15428 2/20 0.68
HSD17B10 Q99714 1/20 0.68
MAPT P10636 1/20 0.64
RXFP1 Q9HBX9 1/20 0.64
HDAC1 Q13547 4/20 0.63
GAA P10253 2/20 0.63
ABCC4 O15439 1/20 0.63
LMNA P02545 1/20 0.63
TSHR P16473 1/20 0.63
PTGS1 P23219 1/20 0.63
HTT P42858 1/20 0.63
HDAC3 O15379 1/20 0.63
MAPK1 P28482 1/20 0.63
ADRA1A P35348 1/20 0.63
HDAC4 P56524 1/20 0.63
SLC6A3 Q01959 1/20 0.63
SMN1; SMN2 Q16637 1/20 0.63
HDAC7 Q8WUI4 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7821192 0.96 AKR1B1 (0.74) AKR1B1ALDH1A1HPGDHSD17B10MAPT
SCHEMBL11423252 0.93 ALDH1A1 (0.80) AKR1B1ALDH1A1HPGDHSD17B10MAPT
SCHEMBL11426403 0.91 ALDH1A1 (0.77) AKR1B1ALDH1A1HPGDHSD17B10MAPT
SCHEMBL11424079 0.91 ALDH1A1 (0.77) AKR1B1ALDH1A1HPGDHSD17B10MAPT
SCHEMBL3961745 0.91 AKR1B1 (0.81) AKR1B1ALDH1A1HPGDHSD17B10MAPT
SCHEMBL11432001 0.91 ALDH1A1 (0.77) AKR1B1ALDH1A1HPGDHSD17B10MAPT
SCHEMBL11431995 0.91 ALDH1A1 (0.77) AKR1B1ALDH1A1HPGDHSD17B10MAPT
SCHEMBL7820960 0.89 HSD17B10 (0.76) AKR1B1ALDH1A1HPGDHSD17B10MAPT
Phenylbutanoic Acid SCHEMBL7703557 0.88 HDAC1 (0.84) AKR1B1ALDH1A1HPGDHSD17B10MAPT
Phenylacetic Acid SCHEMBL13618842 0.86 AKR1B1 (1.00) AKR1B1GAAABCC4LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014138989-A1 METHOD AND INTERMEDIATES FOR THE SYNTHESIS OF HYDROXAMIC ACID COMPOUNDS METHYLGENE INC. (CA) 2014-09-18 WO claimed
WO-2014138989-A1 METHOD AND INTERMEDIATES FOR THE SYNTHESIS OF HYDROXAMIC ACID COMPOUNDS METHYLGENE INC. (CA) 2014-09-18 WO disclosed
WO-2014138989-A1 METHOD AND INTERMEDIATES FOR THE SYNTHESIS OF HYDROXAMIC ACID COMPOUNDS METHYLGENE INC. (CA) 2014-09-18 WO disclosed
EP-2573069-A2 Inhibitors of histone deacetylase and prodrugs thereof MethylGene Inc. (CA) 2013-03-27 EP disclosed
EP-1973872-A1 INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF Methylgene, Inc. (CA) 2008-10-01 EP disclosed
WO-2008074132-A1 INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF METHYLGENE INC. (CA) 2008-06-26 WO disclosed