Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL396053 | 0.92 | SMN1; SMN2 (0.57) | SMN1; SMN2TDP1GAAKMT2AMEN1 | |
| SCHEMBL5485824 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2TDP1ALDH1A1GAAKMT2A | |
| SCHEMBL4326710 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2TDP1CYP3A4ALDH1A1ALOX15 | |
| SCHEMBL6354542 | 0.83 | MAPT (0.56) | SMN1; SMN2TDP1CYP3A4ALDH1A1ALOX15 | |
| SCHEMBL398996 | 0.81 | TDP1 (0.62) | TDP1CYP3A4ALDH1A1ALOX15GAA | |
| SCHEMBL5455180 | 0.80 | GAA (0.64) | SMN1; SMN2TDP1ALDH1A1GAAKMT2A | |
| SCHEMBL2230525 | 0.78 | KMT2A (0.52) | SMN1; SMN2TDP1ALDH1A1GAAKMT2A | |
| SCHEMBL2230530 | 0.78 | KMT2A (0.52) | SMN1; SMN2TDP1ALDH1A1GAAKMT2A | |
| SCHEMBL30661616 | 0.78 | KMT2A (0.47) | SMN1; SMN2TDP1ALDH1A1GAAKMT2A | |
| SCHEMBL2144447 | 0.78 | KMT2A (0.47) | SMN1; SMN2TDP1ALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971604-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | Amgen Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007048070-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC. (US) | 2007-04-26 | — | — | WO | disclosed |