SCHEMBL4970860

SCHEMBL4970860

O=C(O)C#Cc1ccc(C(=O)O)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 2/20 0.55
RARG P13631 2/20 0.55
TSHR P16473 3/20 0.55
TP53 P04637 1/20 0.55
PTPN11 Q06124 1/20 0.52
SRD5A2 P31213 2/20 0.48
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA12 O43570 1/20 0.46
CA3 P07451 1/20 0.46
TYR P14679 1/20 0.46
DRD1 P21728 1/20 0.46
CA4 P22748 1/20 0.46
CA6 P23280 1/20 0.46
CA5A P35218 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
CA5B Q9Y2D0 1/20 0.46
CYP26A1 O43174 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9629232 0.88 FFAR1 (0.50) ALDH1A1SMN1; SMN2VCPFFAR1APP
SCHEMBL29789030 0.85 RARB (0.69) RARBRARGTSHRTP53PTPN11
SCHEMBL69572 0.85 RARB (0.69) RARBRARGTSHRTP53PTPN11
Hydrochloric Acid SCHEMBL5666955 0.83 RARB (0.67) RARBRARGTSHRTP53PTPN11
SCHEMBL28950553 0.83 MAPT (0.47) RARBRARGALDH1A1SMN1; SMN2VCP
SCHEMBL2679567 0.81 TSHR (0.60) RARBRARGTSHRTP53PTPN11
SCHEMBL19433669 0.79 RARB (0.62) RARBRARGTSHRTP53PTPN11
SCHEMBL20026796 0.79 RARB (0.62) RARBRARGTSHRTP53PTPN11
SCHEMBL402518 0.79 RARB (0.62) RARBRARGTSHRTP53PTPN11
SCHEMBL29023297 0.79 SRD5A2 (0.71) RARBRARGTSHRTP53PTPN11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2730559-A1 DEUTERATED PHENYLPROPIONIC ACID DERIVATIVE Research Foundation Itsuu Laboratory (JP) 2014-05-14 EP disclosed
US-20140121407-A1 DEUTERATED PHENYLPROPIONIC ACID DERIVATIVE RESEARCH FOUNDATION ITSUU LABORATORY (JP) 2014-05-01 US disclosed
EP-0980016-B1 ALIGNING AGENT FOR LIQUID CRYSTAL NISSAN CHEMICAL IND LTD (JP) 2008-09-24 EP disclosed
EP-0980016-A1 ALIGNING AGENT FOR LIQUID CRYSTAL Nissan Chemical Industries, Ltd. (JP) 2000-02-16 EP disclosed