Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15330912 | 0.78 | AR (0.56) | ARELANEOPRM1OPRD1OPRK1 | |
| SCHEMBL15665470 | 0.76 | ELANE (0.54) | ARELANEOPRM1OPRD1OPRK1 | |
| SCHEMBL2172636 | 0.76 | ELANE (0.54) | ARELANEOPRM1OPRD1OPRK1 | |
| SCHEMBL3347621 | 0.76 | ELANE (0.54) | ARELANEOPRM1OPRD1OPRK1 | |
| SCHEMBL28510719 | 0.75 | AR (0.50) | ARELANEOPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL27002674 | 0.75 | ELANE (0.53) | ARELANEOPRM1OPRD1OPRK1 | |
| SCHEMBL5736480 | 0.75 | ITGB3 (0.53) | MAPK1ALDH1A1DPP4 | |
| SCHEMBL2555259 | 0.74 | AR (0.52) | ARELANEOPRM1OPRD1OPRK1 | |
| SCHEMBL7497512 | 0.72 | ELANE (0.50) | ARELANEOPRM1OPRD1OPRK1 | |
| SCHEMBL27534007 | 0.72 | ELANE (0.50) | ARELANEOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888563-A1 | PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006127550-A1 | PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-11-30 | — | — | WO | disclosed |