Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.46 |
| ▸ | JAK3 | P52333 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972038 | 0.89 | JAK2 (0.49) | JAK2JAK3SMN1; SMN2NTRK1KCNH2 | |
| SCHEMBL4972541 | 0.86 | JAK2 (0.46) | JAK2JAK3SMN1; SMN2NTRK1KCNH2 | |
| SCHEMBL4974714 | 0.83 | JAK2 (0.47) | JAK2JAK3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4973163 | 0.83 | JAK2 (0.63) | JAK2JAK3SMN1; SMN2NTRK1KCNH2 | |
| SCHEMBL4972196 | 0.83 | JAK2 (0.45) | JAK2JAK3SMN1; SMN2NTRK1KCNH2 | |
| SCHEMBL4972257 | 0.80 | JAK2 (0.59) | JAK2JAK3SMN1; SMN2NTRK1KCNH2 | |
| SCHEMBL4972182 | 0.78 | JAK2 (0.48) | JAK2JAK3SMN1; SMN2NTRK1KCNH2 | |
| SCHEMBL4973170 | 0.78 | JAK2 (0.39) | JAK2JAK3MTORKDM4EABL1 | |
| SCHEMBL4972548 | 0.75 | JAK2 (0.46) | JAK2JAK3SMN1; SMN2NTRK1KCNH2 | |
| SCHEMBL4972207 | 0.75 | JAK2 (0.64) | JAK2JAK3NTRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |