Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | BCR | P11274 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | STK4 | Q13043 | 1/20 | 0.36 |
| ▸ | STK3 | Q13188 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975393 | 0.86 | JAK2 (0.38) | JAK2JAK3KDM4EELOVL1TSHR | |
| SCHEMBL4970852 | 0.82 | JAK2 (0.40) | JAK2JAK3KDM4EELOVL1TSHR | |
| SCHEMBL4972215 | 0.80 | JAK2 (0.39) | JAK2JAK3KDM4ESTK4STK3 | |
| SCHEMBL4972050 | 0.78 | JAK2 (0.46) | JAK2JAK3KDM4EABL1MTOR | |
| SCHEMBL4972038 | 0.77 | JAK2 (0.49) | JAK2JAK3KDM4EHSD17B10ABL1 | |
| SCHEMBL4973163 | 0.76 | JAK2 (0.63) | JAK2JAK3KDM4E | |
| SCHEMBL4973061 | 0.76 | JAK2 (0.41) | JAK2JAK3KDM4EABL1BCR | |
| SCHEMBL4972541 | 0.74 | JAK2 (0.46) | JAK2JAK3KDM4EHSD17B10MTOR | |
| SCHEMBL4972257 | 0.73 | JAK2 (0.59) | JAK2JAK3KDM4E | |
| SCHEMBL4975389 | 0.72 | JAK2 (0.61) | JAK2JAK3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |