SCHEMBL4972062

SCHEMBL4972062

COc1ccc(NC(=O)c2cc(=O)c3ccccc3o2)cc1OC

nearest known ligand 0.81

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 10/20 0.81
DUSP3 P51452 1/20 0.81
PTPN11 Q06124 1/20 0.81
MEN1 O00255 8/20 0.72
RAB9A P51151 3/20 0.72
MAPT P10636 6/20 0.68
ALDH1A1 P00352 2/20 0.68
KDM4E B2RXH2 1/20 0.68
L3MBTL1 Q9Y468 1/20 0.68
POLB P06746 2/20 0.68
NPC1 O15118 2/20 0.68
HTT P42858 2/20 0.68
SMN1; SMN2 Q16637 1/20 0.68
LMNA P02545 1/20 0.67
MAOB P27338 3/20 0.67
MAOA P21397 2/20 0.67
RXFP1 Q9HBX9 1/20 0.64
ADORA2B P29275 1/20 0.60
ABCB1 P08183 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4971240 0.91 KMT2A (0.78) KMT2ADUSP3PTPN11MEN1RAB9A
SCHEMBL6952512 0.88 KMT2A (0.71) KMT2ADUSP3PTPN11MEN1RAB9A
SCHEMBL25308135 0.86 KMT2A (0.69) KMT2ADUSP3PTPN11MEN1RAB9A
SCHEMBL30663838 0.86 KMT2A (0.69) KMT2ADUSP3PTPN11MEN1RAB9A
SCHEMBL12501713 0.85 KMT2A (0.78) KMT2ADUSP3PTPN11MEN1RAB9A
SCHEMBL28639941 0.84 KMT2A (0.69) KMT2ADUSP3PTPN11MEN1RAB9A
SCHEMBL29923968 0.84 KMT2A (0.69) KMT2ADUSP3PTPN11MEN1RAB9A
SCHEMBL30643083 0.83 ABCG2 (0.62) KMT2ADUSP3PTPN11MEN1RAB9A
SCHEMBL4970562 0.81 MAOB (0.82) KMT2AMEN1RAB9AMAPTALDH1A1
SCHEMBL25343302 0.81 ABCB1 (0.69) KMT2ADUSP3PTPN11MEN1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008104925-A1 CHROMONE DERIVATIVES FOR USE AS ANTIOXIDANTS/PRESERVATIVES UNIVERSIDADE DO PORTO (PT) 2008-09-04 WO claimed
WO-2008104925-A1 CHROMONE DERIVATIVES FOR USE AS ANTIOXIDANTS/PRESERVATIVES UNIVERSIDADE DO PORTO (PT) 2008-09-04 WO disclosed