Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4110091 | 1.00 | LMNA (0.70) | LMNAGAABCAT1ALDH1A1KMT2A | |
| SCHEMBL8264035 | 0.89 | LMNA (0.67) | LMNAGAABCAT1ALDH1A1KMT2A | |
| SCHEMBL5806490 | 0.86 | LMNA (0.63) | LMNAGAABCAT1ALDH1A1KMT2A | |
| SCHEMBL5806497 | 0.86 | LMNA (0.63) | LMNAGAABCAT1ALDH1A1KMT2A | |
| SCHEMBL5804505 | 0.85 | LMNA (0.61) | LMNAGAABCAT1ALDH1A1KMT2A | |
| SCHEMBL5804502 | 0.85 | LMNA (0.61) | LMNAGAABCAT1ALDH1A1KMT2A | |
| SCHEMBL15761364 | 0.82 | GAA (1.00) | LMNAGAAALDH1A1KMT2AKDM4E | |
| SCHEMBL29751607 | 0.82 | GAA (1.00) | LMNAGAAALDH1A1KMT2AKDM4E | |
| SCHEMBL5779512 | 0.81 | LMNA (0.66) | LMNAGAABCAT1ALDH1A1KMT2A | |
| SCHEMBL3527258 | 0.81 | LMNA (0.71) | LMNAGAABCAT1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| EP-3458443-A1 | AROMATIC SULFONAMIDE DERIVATIVES | Bayer Pharma Aktiengesellschaft (DE) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017191000-A9 | AROMATIC SULFONAMIDE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-12-27 | — | — | WO | disclosed |
| WO-2017191000-A1 | AROMATIC SULFONAMIDE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-11-09 | — | — | WO | disclosed |
| WO-2017165256-A1 | ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2017-09-28 | — | — | WO | disclosed |
| EP-1956907-A2 | CYANOBENZENE COMPOUNDS FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007060220-A2 | CYANOBENZENE COMPOUNDS FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2007-05-31 | — | — | WO | disclosed |