Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969870 | 0.92 | SMO (0.50) | SMOMCHR1DGAT1RAB9ALMNA | |
| SCHEMBL4971602 | 0.92 | SMO (0.52) | SMOMCHR1KCNH2RAB9ALMNA | |
| SCHEMBL402625 | 0.91 | SMO (0.60) | SMOMAPK8MCHR1KCNH2DGAT1 | |
| SCHEMBL4970492 | 0.89 | SMO (0.52) | SMOMAPK8MCHR1KCNH2DGAT1 | |
| SCHEMBL4975497 | 0.88 | KCNH2 (0.57) | SMOMAPK8KCNH2RAB9ALMNA | |
| SCHEMBL10238407 | 0.87 | SMO (0.56) | SMOALDH1A1HDAC2 | |
| SCHEMBL399857 | 0.87 | MAPT (0.57) | SMOMAPK8MCHR1RAB9ALMNA | |
| SCHEMBL404073 | 0.87 | SMO (0.59) | SMOMAPK8MCHR1RAB9ALMNA | |
| SCHEMBL4972268 | 0.86 | SMO (0.52) | SMORAB9ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL10238332 | 0.85 | SMO (0.58) | SMORAB9ALMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |