SCHEMBL4969870

SCHEMBL4969870

O=C(Nc1ccc(Cl)c(Nc2ccc(F)cc2)c1)c1ccc(N2CCC(O)CC2)nc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMO Q99835 1/20 0.50
KCNQ3 O43525 2/20 0.48
KCNQ2 O43526 2/20 0.48
SMN1; SMN2 Q16637 4/20 0.46
RAB9A P51151 3/20 0.46
MAPT P10636 2/20 0.46
LMNA P02545 1/20 0.46
HTT P42858 1/20 0.46
HDAC10 Q969S8 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
HDAC3 O15379 1/20 0.46
HDAC2 Q92769 1/20 0.46
IKBKB O14920 1/20 0.45
MAPK7 Q13164 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL399777 0.94 SMO (0.55) SMOKCNQ3KCNQ2SMN1; SMN2RAB9A
SCHEMBL4972254 0.92 SMO (0.53) SMOKCNQ3KCNQ2SMN1; SMN2RAB9A
SCHEMBL4971602 0.91 SMO (0.52) SMOKCNQ3KCNQ2SMN1; SMN2RAB9A
SCHEMBL4970125 0.88 SMO (0.48) SMOKCNQ3KCNQ2SMN1; SMN2RAB9A
SCHEMBL4968097 0.88 HDAC2 (0.60) SMOKCNQ3KCNQ2SMN1; SMN2RAB9A
SCHEMBL400560 0.86 SMO (0.61) SMOKCNQ3KCNQ2SMN1; SMN2RAB9A
SCHEMBL4971048 0.86 RAB9A (0.50) SMOKCNQ3KCNQ2SMN1; SMN2RAB9A
SCHEMBL404073 0.86 SMO (0.59) SMOKCNQ3KCNQ2SMN1; SMN2RAB9A
SCHEMBL4969481 0.85 CHRM1 (0.52) SMOKCNQ3KCNQ2SMN1; SMN2RAB9A
SCHEMBL402625 0.85 SMO (0.60) SMOSMN1; SMN2RAB9AMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1957461-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING Genentech, Inc. (US) 2008-08-20 EP claimed
WO-2007059157-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING GENENTECH, INC. (US) 2007-05-24 WO claimed
EP-1957461-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING Genentech, Inc. (US) 2008-08-20 EP disclosed
WO-2007059157-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING GENENTECH, INC. (US) 2007-05-24 WO disclosed