Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497268 | 0.84 | ALDH1A1 (0.41) | MOGAT2CNR2LTA4HLMNASMN1; SMN2 | |
| SCHEMBL3805223 | 0.83 | ALDH1A1 (0.45) | LTA4HLMNASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL81946 | 0.83 | ALDH1A1 (0.45) | LTA4HLMNASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL82653 | 0.82 | ALDH1A1 (0.40) | CYP2D6OPRK1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5538246 | 0.82 | GRIN1 (0.48) | MOGAT2CNR2LTA4HLMNASMN1; SMN2 | |
| SCHEMBL82791 | 0.82 | GRIN1 (0.48) | MOGAT2CNR2LTA4HLMNASMN1; SMN2 | |
| SCHEMBL5506542 | 0.82 | GRIN1 (0.48) | MOGAT2CNR2LTA4HLMNASMN1; SMN2 | |
| SCHEMBL82792 | 0.82 | GRIN1 (0.48) | MOGAT2CNR2LTA4HLMNASMN1; SMN2 | |
| SCHEMBL83032 | 0.80 | ALDH1A1 (0.42) | LTA4HLMNASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL83427 | 0.80 | ALDH1A1 (0.43) | MOGAT2LTA4HCYP2D6LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106045-B2 | 2-morpholino-4-pyrimidone compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-01-31 | — | — | US | disclosed |
| EP-1805164-B9 | 6-(PYRIDINYL)-4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-09-07 | — | — | EP | disclosed |
| EP-1805164-B1 | 6-(PYRIDINYL)-4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-02-23 | — | — | EP | disclosed |
| EP-2266979-A1 | 2-morpholino-4-pyrimidone compounds | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-12-29 | — | — | EP | disclosed |