Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2001283 | 0.65 | KDM4E (0.37) | MAPK1KDM4EHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL17413784 | 0.65 | HRH4 (0.49) | MAPK1KDM4EHSD17B10LMNAHTT | |
| SCHEMBL2077314 | 0.62 | MAPK1 (0.96) | MAPK1KDM4EHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL2077312 | 0.61 | MAPK1 (0.67) | MAPK1KDM4EHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL1774454 | 0.60 | LMNA (0.66) | MAPK1KDM4EHSD17B10SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL23068261 | 0.59 | LMNA (0.64) | MAPK1KDM4EHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL9572239 | 0.58 | LMNA (0.50) | MAPK1KDM4EHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL6051869 | 0.57 | BRD4 (0.45) | MAPK1KDM4EHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL873114 | 0.57 | AKT2 (1.00) | MAPK1CHEK1AKT2KMT2ANPSR1 | |
| SCHEMBL628152 | 0.57 | MEN1 (0.50) | SMN1; SMN2MAPTTSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008016643-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |