Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29235105 | 0.79 | ALDH1A1 (0.36) | KDM4EALDH1A1PDE10AEGLN2AOC3 | |
| SCHEMBL4978816 | 0.78 | JAK2 (0.42) | PDE10A | |
| SCHEMBL4975153 | 0.76 | MAOB (0.36) | ALDH1A1PDE10ACHRM3PDE4APDE4B | |
| SCHEMBL31553840 | 0.75 | ALDH1A1 (0.34) | KDM4EALDH1A1PDE10ACHRM3PDE4A | |
| SCHEMBL25079306 | 0.75 | ALDH1A1 (0.34) | KDM4EALDH1A1PDE10ACHRM3PDE4A | |
| SCHEMBL30623545 | 0.73 | EGLN1 (0.34) | KDM4EALDH1A1PDE10AEGLN1SMN1; SMN2 | |
| SCHEMBL2337541 | 0.72 | SMN1; SMN2 (0.44) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1290498 | 0.71 | ALDH1A1 (0.38) | KDM4EALDH1A1PDE10AEGLN2EGLN1 | |
| SCHEMBL25240418 | 0.70 | ALDH1A1 (0.34) | KDM4EALDH1A1EGLN1SMN1; SMN2HRH3 | |
| SCHEMBL25295544 | 0.70 | ALDH1A1 (0.42) | KDM4EALDH1A1PDE10ACHRM3PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |