Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL134813 | 0.83 | AGBL2 (0.43) | AGBL2ADORA2A | |
| SCHEMBL29941432 | 0.83 | AGBL2 (0.43) | AGBL2ADORA2A | |
| SCHEMBL29877399 | 0.81 | AGBL2 (0.38) | AGBL2ADORA2A | |
| SCHEMBL1396051 | 0.81 | AGBL2 (0.38) | AGBL2ADORA2A | |
| SCHEMBL17512545 | 0.80 | TKT (0.30) | — | |
| Hydrochloric Acid SCHEMBL1396013 | 0.79 | TDP1 (0.37) | AGBL2 | |
| Hydrochloric Acid SCHEMBL3233626 | 0.79 | TDP1 (0.37) | AGBL2 | |
| SCHEMBL30519756 | 0.79 | AGBL2 (0.41) | AGBL2ADORA2A | |
| SCHEMBL10115987 | 0.79 | AGBL2 (0.41) | AGBL2ADORA2A | |
| SCHEMBL29475250 | 0.79 | AGBL2 (0.41) | AGBL2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |