Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 15/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14244157 | 0.84 | CETP (0.47) | CETPEPHX1LMNA | |
| SCHEMBL760548 | 0.80 | CETP (0.42) | CETPEPHX1LMNAOPRL1 | |
| SCHEMBL760727 | 0.75 | CETP (0.68) | CETP | |
| SCHEMBL760726 | 0.75 | CETP (0.68) | CETP | |
| SCHEMBL762000 | 0.70 | EPHX2 (0.47) | CETPEPHX1LMNA | |
| SCHEMBL760148 | 0.67 | CETP (0.69) | CETP | |
| SCHEMBL760147 | 0.67 | CETP (0.69) | CETP | |
| SCHEMBL4968308 | 0.65 | NPSR1 (0.44) | LMNA | |
| SCHEMBL760181 | 0.65 | CETP (0.68) | CETP | |
| SCHEMBL760180 | 0.65 | CETP (0.68) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954668-A2 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062308-A2 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |