Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 12/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14244157 | 0.90 | CETP (0.47) | CETPEPHX1LMNAEPHX2 | |
| SCHEMBL4973254 | 0.80 | CETP (0.42) | CETPEPHX1LMNAOPRL1 | |
| SCHEMBL762000 | 0.73 | EPHX2 (0.47) | CETPEPHX1LMNAEPHX2 | |
| SCHEMBL1242372 | 0.72 | ALDH1A1 (0.50) | EPHX1LMNA | |
| SCHEMBL758760 | 0.71 | CETP (0.69) | CETP | |
| SCHEMBL761349 | 0.71 | CETP (0.69) | CETP | |
| SCHEMBL758759 | 0.71 | CETP (0.69) | CETP | |
| SCHEMBL8067568 | 0.68 | EPHX1 (0.73) | EPHX1LMNAEPHX2CNR1CNR2 | |
| SCHEMBL757372 | 0.67 | CETP (0.73) | CETP | |
| SCHEMBL761559 | 0.67 | CETP (0.73) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954668-B9 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-1954668-B1 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-09-28 | — | — | EP | disclosed |