Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9408756 | 0.84 | NPC1 (0.39) | NPC1RAB9ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL11408530 | 0.83 | NPC1 (0.34) | NPC1RAB9ALMNAPOLBALDH1A1 | |
| SCHEMBL9408810 | 0.82 | NPC1 (0.39) | NPC1RAB9ALMNAPOLBSMN1; SMN2 | |
| SCHEMBL11329476 | 0.80 | NPC1 (0.47) | NPC1RAB9ALMNAPOLBALDH1A1 | |
| SCHEMBL285622 | 0.78 | NPC1 (0.58) | NPC1RAB9ALMNAPOLBALDH1A1 | |
| SCHEMBL29394296 | 0.78 | NPC1 (0.58) | NPC1RAB9ALMNAPOLBALDH1A1 | |
| SCHEMBL4979055 | 0.76 | NPC1 (0.43) | NPC1RAB9ALMNAPOLBALDH1A1 | |
| SCHEMBL4974243 | 0.76 | NPC1 (0.33) | NPC1RAB9ALMNAPOLB | |
| SCHEMBL4977461 | 0.76 | NPC1 (0.33) | NPC1RAB9ALMNAPOLB | |
| SCHEMBL562624 | 0.73 | NPC1 (0.54) | NPC1RAB9ALMNADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008131921-A1 | SILYLATED, SUBSTITUTED BENZOTRIAZOLYLPHENOL COMPOUNDS | ISDIN S.A. (ES) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008131921-A1 | SILYLATED, SUBSTITUTED BENZOTRIAZOLYLPHENOL COMPOUNDS | ISDIN S.A. (ES) | 2008-11-06 | — | — | WO | disclosed |