Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 4/20 | 0.79 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140 | 0.89 | ENPP2 (1.00) | ENPP2CA1CA2RELANPC1 | |
| SCHEMBL7344145 | 0.89 | ENPP2 (1.00) | ENPP2CA1CA2RELANPC1 | |
| Methyl Alcohol SCHEMBL28712606 | 0.87 | ENPP2 (0.96) | ENPP2CA1CA2RELANPC1 | |
| SCHEMBL11815 | 0.83 | ENPP2 (0.56) | ENPP2CA1CA2EGFR | |
| SCHEMBL4974695 | 0.83 | ENPP2 (0.54) | ENPP2CA1CA2RELANPC1 | |
| SCHEMBL28060965 | 0.82 | ENPP2 (0.85) | ENPP2CA1CA2NLRP3ACHE | |
| SCHEMBL29563391 | 0.82 | ENPP2 (0.56) | ENPP2CA1CA2LMNA | |
| SCHEMBL29056807 | 0.82 | ENPP2 (0.56) | ENPP2CA1CA2LMNA | |
| SCHEMBL28270052 | 0.81 | ENPP2 (0.50) | ENPP2CA1CA2RELAEGFR | |
| Acetonitrile SCHEMBL28133848 | 0.81 | ENPP2 (0.82) | ENPP2CA1CA2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |