Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4974880 | 1.00 | TSHR (0.42) | TSHRHTTMAPTRENALDH1A1 | |
| SCHEMBL2330057 | 0.88 | CNR1 (0.40) | TSHRHTTMAPTRENALDH1A1 | |
| SCHEMBL2330054 | 0.88 | CNR1 (0.40) | TSHRHTTMAPTRENALDH1A1 | |
| SCHEMBL2330051 | 0.88 | CNR1 (0.40) | TSHRHTTMAPTRENALDH1A1 | |
| SCHEMBL971027 | 0.85 | REN (0.51) | TSHRMAPTRENALDH1A1LMNA | |
| SCHEMBL971028 | 0.85 | REN (0.51) | TSHRMAPTRENALDH1A1LMNA | |
| SCHEMBL2330517 | 0.81 | REN (0.42) | TSHRHTTRENLMNASMN1; SMN2 | |
| SCHEMBL5510885 | 0.81 | REN (0.49) | TSHRHTTRENALDH1A1POLB | |
| SCHEMBL2330515 | 0.81 | REN (0.42) | TSHRHTTRENLMNASMN1; SMN2 | |
| SCHEMBL4193014 | 0.81 | REN (0.59) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966139-A1 | ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070201-A1 | ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |