Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 11/20 | 0.38 |
| ▸ | PRKCI | P41743 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | INSR | P06213 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | LYN | P07948 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20816501 | 0.79 | FLT1 (0.62) | KDRPRKCIPLK4AURKAMAPK13 | |
| SCHEMBL29923744 | 0.79 | FLT1 (0.62) | KDRPRKCIPLK4AURKAMAPK13 | |
| SCHEMBL27661088 | 0.76 | KDR (0.64) | KDRPLK4AURKAMAPK13PDPK1 | |
| SCHEMBL27661161 | 0.76 | KDR (0.57) | KDRPLK4AURKAMAPK13PDPK1 | |
| SCHEMBL4962802 | 0.76 | ANO1 (0.49) | KDRPLK4AURKAMAPK13PDPK1 | |
| SCHEMBL4964462 | 0.75 | KIT (0.64) | KDRPLK4AURKAMAPK13PDPK1 | |
| SCHEMBL28760558 | 0.74 | KDR (0.53) | KDRPRKCIPLK4AURKAMAPK13 | |
| SCHEMBL27640551 | 0.74 | BRAF (0.61) | KDRPLK4AURKAMAPK13PDPK1 | |
| SCHEMBL28760603 | 0.74 | KDR (0.53) | KDRPRKCIPLK4AURKAMAPK13 | |
| SCHEMBL27657281 | 0.73 | KDR (0.47) | KDRAURKAPDPK1CHEK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436279-B1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-08-13 | — | — | EP | disclosed |