Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975344 | 0.89 | LTA4H (0.55) | LTA4HSMN1; SMN2CA1CA2CA4 | |
| SCHEMBL12520647 | 0.85 | LTA4H (0.63) | LTA4HSMN1; SMN2SIGMAR1 | |
| SCHEMBL4287551 | 0.85 | LTA4H (0.63) | LTA4HSMN1; SMN2SIGMAR1 | |
| SCHEMBL3494681 | 0.84 | LTA4H (0.64) | LTA4HCA1CA2CA4CA9 | |
| SCHEMBL18325 | 0.83 | LTA4H (0.61) | LTA4HALDH1A1CA1CA2CA4 | |
| SCHEMBL3491795 | 0.83 | LTA4H (0.61) | LTA4HALDH1A1CA1CA2CA4 | |
| SCHEMBL24350 | 0.83 | LTA4H (0.61) | LTA4HALDH1A1CA1CA2CA4 | |
| SCHEMBL3493753 | 0.81 | LTA4H (0.57) | LTA4HALDH1A1CA1CA2CA4 | |
| SCHEMBL3493797 | 0.81 | LTA4H (0.57) | LTA4HALDH1A1CA1CA2CA4 | |
| SCHEMBL3495252 | 0.81 | MAPK1 (0.52) | LTA4HSMN1; SMN2ALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |