Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.46 |
| ▸ | JAK3 | P52333 | 12/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | GPR6 | P46095 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972492 | 0.88 | JAK2 (0.36) | JAK2JAK3 | |
| SCHEMBL4969772 | 0.88 | JAK2 (0.48) | JAK2JAK3SMN1; SMN2BCL6KDM4E | |
| SCHEMBL4972196 | 0.84 | JAK2 (0.45) | JAK2JAK3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4974714 | 0.83 | JAK2 (0.47) | JAK2JAK3SMN1; SMN2BCL6KDM4E | |
| SCHEMBL4975403 | 0.83 | JAK2 (0.49) | JAK2JAK3SMN1; SMN2BCL6KDM4E | |
| SCHEMBL4974705 | 0.80 | JAK2 (0.49) | JAK2JAK3SMN1; SMN2BCL6KDM4E | |
| SCHEMBL4972221 | 0.79 | JAK2 (0.61) | JAK2JAK3SMN1; SMN2BCL6KDM4E | |
| SCHEMBL4970845 | 0.76 | JAK2 (0.64) | JAK2JAK3SMN1; SMN2BCL6KDM4E | |
| SCHEMBL4969755 | 0.72 | JAK2 (0.50) | JAK2JAK3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4971418 | 0.72 | JAK2 (0.36) | JAK2JAK3GPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |