Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.48 |
| ▸ | JAK3 | P52333 | 12/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972196 | 0.88 | JAK2 (0.45) | JAK2JAK3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4975407 | 0.88 | JAK2 (0.46) | JAK2JAK3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4969755 | 0.82 | JAK2 (0.50) | JAK2JAK3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4980198 | 0.81 | JAK2 (0.64) | JAK2JAK3SMN1; SMN2KDM4E | |
| SCHEMBL4972492 | 0.75 | JAK2 (0.36) | JAK2JAK3 | |
| SCHEMBL4975389 | 0.74 | JAK2 (0.61) | JAK2JAK3SMN1; SMN2KDM4E | |
| SCHEMBL4972215 | 0.74 | JAK2 (0.39) | JAK2JAK3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4972182 | 0.74 | JAK2 (0.48) | JAK2JAK3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4975403 | 0.73 | JAK2 (0.49) | JAK2JAK3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4972207 | 0.72 | JAK2 (0.64) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |