Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 9/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4971600 | 0.95 | RAB9A (0.47) | TRPV1NPC1RAB9ARXFP1PDPK1 | |
| SCHEMBL4969667 | 0.88 | TRPV1 (0.48) | TRPV1NPC1RAB9ARXFP1PDPK1 | |
| SCHEMBL4979584 | 0.84 | RAB9A (0.47) | TRPV1NPC1RAB9ARXFP1PDPK1 | |
| SCHEMBL4970699 | 0.80 | TRPV1 (0.60) | TRPV1NPC1RAB9ARXFP1CASP3 | |
| SCHEMBL1396719 | 0.77 | TRPV1 (0.48) | TRPV1NPC1RAB9ARXFP1PDPK1 | |
| SCHEMBL4972704 | 0.77 | RAB9A (0.46) | TRPV1NPC1RAB9ARXFP1KDR | |
| SCHEMBL4973095 | 0.76 | TRPV1 (0.49) | TRPV1NPC1RAB9ARXFP1CASP3 | |
| SCHEMBL3961761 | 0.76 | KDR (0.63) | TRPV1NPC1RAB9ARXFP1PDPK1 | |
| SCHEMBL4971839 | 0.74 | RAB9A (0.45) | TRPV1NPC1RAB9ARXFP1KDR | |
| SCHEMBL4978180 | 0.74 | NPC1 (0.47) | TRPV1NPC1RAB9ARXFP1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971604-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | Amgen Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007048070-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC. (US) | 2007-04-26 | — | — | WO | disclosed |