Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.52 |
| ▸ | PDE4A | P27815 | 3/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975186 | 0.88 | ALDH1A1 (0.45) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL23466891 | 0.82 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DCHRM2 | |
| SCHEMBL2812864 | 0.82 | NPSR1 (0.50) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL30996468 | 0.82 | SLC6A2 (0.47) | KMT2AMEN1ALDH1A1HRH2HRH1 | |
| SCHEMBL30996465 | 0.82 | SLC6A2 (0.47) | KMT2AMEN1ALDH1A1HRH2HRH1 | |
| SCHEMBL2814379 | 0.82 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL13210805 | 0.82 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL19901712 | 0.79 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL15531867 | 0.79 | HRH2 (0.48) | KMT2AMEN1ALDH1A1HRH2HRH1 | |
| SCHEMBL15514870 | 0.78 | NPSR1 (0.48) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984350-A1 | PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS | Novartis AG (CH) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084786-A1 | PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-07-26 | — | — | WO | disclosed |